Coffee consumption has a long term healthy benefits! In this very latest research article published in Arthritis & Rheumatism has the answer for it! According to Canadian scientists, Choi & Curhan’s research article published in the latest “Arthritis & Rheumatism” journal (see http://www3.interscience.wiley.com/cgi-bin/abstract/114269884/ABSTRACT) as quote:
” The risk of gout was 40% lower with coffee intake of 4-5 cups per day and 59% lower with 6 cups per day, compared with no use. We also found a modest inverse association with decaffeinated coffee consumption. These associations were independent of dietary and other risk factors for gout such as BMI, age, hypertension, diuretic use, alcohol consumption, and chronic renal failure. The current study provides the first prospective data about the inverse association between coffee intake and risk of gout.”
and
“Caffeine (1,3,7-trimethyl xanthine) is metabolized by demethylation, and the major human pathway results in paraxanthine (1,7-dimethyl xanthine), leading to the principal urinary metabolites of l-methyl xanthine, 1-methyl uric acid, and an acetylated uracil derivative. Caffeine and other methyl xanthines were shown to competitively inhibit xanthine oxidase in in vitro and in vivo studies of rats. Similarly, caffeine may reduce the risk of gout via xanthine oxidase inhibition in humans. However, because administration of caffeine lowers insulin sensitivity in humans, this action of caffeine may increase the risk of gout, although these effects may not persist during chronic caffeine consumption. Of note, complete tolerance can develop after several days of caffeine use with respect to humoral and hemodynamic variables such as blood pressure, heart rate, plasma renin activity, plasma catecholamines, or urinary catecholamines. Reflecting these opposing possibilities of the effect of caffeine on the risk of gout, our results suggest that long-term intake of caffeine per se may not be a significant net contributor to the risk of gout.”
What is your view?
Markk said,
May 26, 2007 at 4:02 am
So in others words, drinking of coffee has both positive and negative effects on the risk of gout, but it is positive overall. But the summary seems to contradict the detail section you quoted. Am I reading this correctly?
jason said,
May 27, 2007 at 7:53 am
You are indeed!